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Press Release

EntreMed Presents Preclinical Data for Second Generation 2ME2 Compounds

2ME2 Analogs Show Enhanced Antitumor and Antiangiogenic Activity
April 20, 2005

ROCKVILLE, MD, April 20—EntreMed, Inc. (Nasdaq: ENMD) today announced the presentation of preclinical results for its lead 2-methoxyestradiol (2ME2) analogs. Results from these studies, conducted by EntreMed researchers and their collaborators, were presented at the 96th Annual Meeting of the American Association for Cancer Research (AACR) in Anaheim, California.

EntreMed scientists have modified the chemical structure of 2ME2 to develop analogs with increased antitumor and antiangiogenic properties and improved metabolism while retaining 2ME2’s multiple mechanisms of action. These mechanisms include inducing apoptosis, binding microtubules, and inhibiting HIF-1αlpha. The Company’s 2ME2 analogs demonstrate improved pharmacokinetic parameters, reduced metabolism, and enhanced antitumor activity in preclinical animal models and represent the next generation of molecules with potential for broad application in cancer and other diseases.

Results from a first preclinical study, conducted by EntreMed collaborators, demonstrated enhanced activity of ENMD-1198 both in vitro and in an orthotopic lung cancer model when compared to 2ME2. Furthermore, a dose-dependent increase in survival was observed, indicating the potential for ENMD-1198 in the treatment of human lung cancers.

In a second preclinical study, EntreMed scientists demonstrated that 2ME2 analogs improved median survival time significantly in a metastatic lung cancer model and reduced tumor volumes significantly in a separate orthotopic cancer model. The study further demonstrated that 2ME2 analogs are microtubule destabilizing agents that cause a reduction in HIF-1αlpha protein levels. HIF- 1alpha is over-expressed in more than 70% of human cancers and their metastases, including breast, prostate, head and neck, brain, and lung cancers.

Based on its antitumor activity, enhanced microtubule disruption and HIF- 1alpha inhibition, analog ENMD-1198 is undergoing further preclinical evaluation and IND-directed toxicology studies.

Carolyn F. Sidor, M.D., M.B.A, EntreMed Vice President and Chief Medical Officer, commented on the presentations, “ENMD-1198 retains the mechanisms associated with our lead drug candidate, 2ME2 (Panzem® NCD). This is important, as we believe these molecules represent novel agents. ENMD-1198’s enhanced antitumor activity in multiple models makes it a good candidate for IND-directed studies and we anticipate filing an IND for this compound later in the year.”

To view EntreMed’s poster presentations, visit Scientific Presentations under the Therapeutic Pathways section of the Company’s website at

About EntreMed

EntreMed, Inc. (Nasdaq: ENMD) is a clinical-stage pharmaceutical company developing therapeutic candidates primarily for the treatment of cancer and inflammation. Panzem® (2-methoxyestradiol or 2ME2), the Company’s lead drug candidate, is currently in clinical trials for cancer, as well as in preclinical development for non-oncology indications. EntreMed’s goal is to develop and commercialize new compounds based on the Company’s expertise in angiogenesis, cell cycle regulation and inflammation—processes vital to the treatment of cancer and other diseases, such as rheumatoid arthritis. Additional information about EntreMed is available on the Company’s website at and in various filings with the Securities and Exchange Commission.

Forward Looking Statements

This release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act with respect to the outlook for expectations for future financial or business performance, strategies, expectations and goals. Forward-looking statements are subject to numerous assumptions, risks and uncertainties, which change over time. Forward-looking statements speak only as of the date they are made, and no duty to update forward-looking statements is assumed. Actual results could differ materially from those currently anticipated due to a number of factors, including those set forth in Securities and Exchange Commission filings under “Risk Factors,” including risks relating to the need for additional capital and the uncertainty of additional funding; the early-stage products under development; uncertainties relating to clinical trials; success in the clinical development of any products; dependence on third parties; future capital needs; and risks relating to the commercialization, if any, of the Company’s proposed products (such as marketing, safety, regulatory, patent, product liability, supply, competition and other risks).

CASI Pharmaceuticals, Inc.
Rui Zhang
Solebury Trout
Xuan Yang

About Us

CASI is a U.S. NASDAQ-listed biopharmaceutical company with a platform to develop and accelerate the launch of pharmaceutical products and innovative therapeutics in China, the U.S., and throughout the world. We have offices in Rockville, Maryland, and a wholly owned subsidiary in Beijing, China, through which substantially all of our operations are conducted.

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